Symmetry lies at the heart of the laws of nature that form the basis of modern physics and determine material properties at the fundamental level. By regulating symmetry in mildly oxidized MXene (OXene) architectural composites, we achieve improved out-of-plane conductive pathways and Schottky-induced piezoelectric effects. The broad applicability of this augmented biosensing interface spans various wearable and implantable applications, including microelectrode arrays, gait analysis, active transistor matrices, and wireless signaling transmission. Our findings highlight significant advancements in signal fidelity and reconfigurable logic gates. Additionally, OXene’s high-quality, spatiotemporally resolved physiological recordings in rodent and porcine myocardium, coupled with accurate predictions through machine learning, underscore symmetry engineering in two-dimensional (2D) bioelectronics will facilitate a paradigm shift in diagnostic, monitoring, and therapeutic strategies. Symmetry lies at the heart of two-dimensional (2D) bioelectronics, determining material properties at the fundamental level. Breaking the symmetry allows emergent functionalities and effects. However, symmetry modulation in 2D bioelectronics and the resultant applications have been largely overlooked. Here, we devise an oxidized architectural MXene, referred to as oxidized MXene (OXene), that couples orbit symmetric breaking with inverse symmetric breaking to entitle the optimized interfacial impedance and Schottky-induced piezoelectric effects. The resulting OXene validates applications ranging from microelectrode arrays, gait analysis, active transistor matrix, and wireless signaling transmission, which enables high-fidelity signal transmission and reconfigurable logic gates. Furthermore, OXene interfaces were investigated in both rodent and porcine myocardium, featuring high-quality and spatiotemporally resolved physiological recordings, while accurate differentiated predictions, enabled via various machine learning pipelines.
NeurIPS
NeuroPath: A Neural Pathway Transformer for Joining the Dots of Human Connectomes
Ziquan Wei, Tingting Dan, Jiaqi Ding, and Guorong Wu
In The Thirty-eighth Annual Conference on Neural Information Processing Systems, 2024